Author/Authors :
Argyrios G. Arvanitis، نويسنده , , Joseph T. Rescinito، نويسنده , , Charles R. Arnold، نويسنده , , Richard G. Wilde، نويسنده , , Lawrence W. Fitzgerald، نويسنده , , Robert Zaczek، نويسنده , , Paul R. Hartig، نويسنده , , Scott Grossman، نويسنده , , Stephen P. Arneric، نويسنده , , Paul J. Gilligan، نويسنده , , Richard E. Olson، نويسنده , , David W. Robertson، نويسنده ,
Abstract :
A series of high affinity CRF receptor ligands with an imidazo[4,5-c]pyridine core is described. Individual analogues were synthesized and tested in vitro in rat brain receptors to determine binding affinity. The best compound was further tested in the dog N-in-1 pharmacokinetic model to assess oral bioavailability at 1 mg/kg po.
