Title of article
Studies on the synthesis and anti-Osteoporosis of estrogen-GHRPs linkers
Author/Authors
Chao Wang، نويسنده , , Weina Cui، نويسنده , , Ming Zhao، نويسنده , , Jian Yang، نويسنده , , Shiqi Peng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
143
To page
146
Abstract
The linkers of estrogen-GHRPs were prepared by the combination of estradiol, estrone, TyrGlyGlyPheLeuOH, and TyrGlyGlyPheLeuOH. Their anti-osteoporosis effect was evaluated by analyzing the data, for instance the weight of the body, femur, femur ash, the content of calcium and phosphor in the femur, the content of calcium and ALP activity in the serum, obtained from the corresponding bioassay in vivo. The results indicated that the anti-osteoporosis potency for estradiol, estrone, TyrGlyGlyPheLeuOH and TyrGlyGlyPheLeuNH2 may be totally enhanced each other via the corresponding linkers.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792878
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