Author/Authors :
Yasuyuki Takeda، نويسنده , , Toshiharu Yoshino، نويسنده , , Kouichi Uoto، نويسنده , , Jun Chiba، نويسنده , , Takashi Ishiyama، نويسنده , , Michio Iwahana، نويسنده , , Takeshi Jimbo، نويسنده , , Noriko Tanaka، نويسنده , , Hirofumi Terasawa، نويسنده , , Tsunehiko Soga، نويسنده ,
Abstract :
We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9β-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration.
