Title of article
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid
Author/Authors
Luc J. Farmer، نويسنده , , Lin Zhi، نويسنده , , Susan Jeong، نويسنده , , William W. Lamph، نويسنده , , Deborah L. Osburn، نويسنده , , Glenn Croston، نويسنده , , Karen S. Flatten، نويسنده , , Rich A. Heyman، نويسنده , , Alex M. Nadzan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
261
To page
264
Abstract
A series of novel cyclopropanyl methyl hexadienoic acid retinoids was designed and prepared. These compounds exhibited either selective activity as RXR agonists or pan-agonists on one or more of each of the RAR and RXR isoforms. The most potent pan-agonist 5a (RARʹs EC50=17–59 nM; RXRʹs EC50=6–14 nM) showed good antiproliferative properties in the in vitro cancer cell lines, ME 180 and RPMI 8226.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792902
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