Author/Authors :
Adriana S. Veleiro، نويسنده , , Ruth E. Rosenstein، نويسنده , , Carolina O. Jaliffa، نويسنده , , Mar?a L. Grilli، نويسنده , , Florencia Speroni، نويسنده , , Gerardo Burton، نويسنده ,
Abstract :
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl− influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid.
