Title of article
Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide
Author/Authors
Joshua J. Higgin، نويسنده , , Gennady I. Yakovlev، نويسنده , , Vladimir A. Mitkevich، نويسنده , , Alexander A. Makarov، نويسنده , , Ronald T. Raines، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
409
To page
412
Abstract
The inhibition of ribonuclease Bi by 3′-N-hydroxyurea-3′-deoxythymidine 5′-phosphate is enhanced by 30-fold in the presence of Zn2+. Thus, an N-hydroxyurea nucleotide can recruit Zn2+ to inhibit the enzymatic activity of a ribonuclease. This result engenders a general strategy for the inhibition of non-metalloenzymes by metal complexes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792934
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