Author/Authors :
Yung Hyup Joo، نويسنده , , Jin-Kwan Kim، نويسنده , , Seon-Hwa Kang، نويسنده , , Min-Soo Noh، نويسنده , , Jun-Yong Ha، نويسنده , , Jin Kyu Choi، نويسنده , , Kyung-Min Lim، نويسنده , , Chang Hoon Lee، نويسنده , , Chia-Shin Chung، نويسنده ,
Abstract :
A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.
