Author/Authors :
Vinod R. Hegde، نويسنده , , Mohindar S. Puar، نويسنده , , Ping Dai، نويسنده , , Mahesh Patel، نويسنده , , Vincent P. Gullo، نويسنده , , Tze-Ming Chan، نويسنده , , Jack Silver، نويسنده , , Birendra N. Pramanik، نويسنده , , Chung-Her Jenh، نويسنده ,
Abstract :
Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28–CD80 binding with an IC50 of 0.42, 0.38 and 0.22 μM, respectively.
