Title of article
Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28–CD80 interactions
Author/Authors
Vinod R. Hegde، نويسنده , , Mohindar S. Puar، نويسنده , , Ping Dai، نويسنده , , Mahesh Patel، نويسنده , , Vincent P. Gullo، نويسنده , , Tze-Ming Chan، نويسنده , , Jack Silver، نويسنده , , Birendra N. Pramanik، نويسنده , , Chung-Her Jenh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
573
To page
575
Abstract
Three condensed aromatic peptides SCH79235 (1), SCH79236 (2), and SCH204698 (3) were isolated from the fermentation broth of a Streptomycete microorganism. The structure of SCH204698 (3) was established by extensive NMR spectral data. All these compounds exhibited good activity against CD28–CD80 binding with an IC50 of 0.42, 0.38 and 0.22 μM, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792968
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