Author/Authors :
Richard L. Jarvest، نويسنده , , John M. Berge، نويسنده , , Murray J. Brown، نويسنده , , Pamela Brown، نويسنده , , John S. Elder، نويسنده , , Andrew K. Forrest، نويسنده , , C. S. V. Houge-Frydrych، نويسنده , , Peter J. OʹHanlon، نويسنده , , David J. McNair، نويسنده , , Stephen Rittenhouse، نويسنده , , Robert J. Sheppard، نويسنده ,
Abstract :
Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.
