Author/Authors :
Neil R. Curtis، نويسنده , , Helen J. Diggle، نويسنده , , Janusz J. Kulagowski، نويسنده , , Clare London، نويسنده , , Sarah Grimwood، نويسنده , , Peter H. Hutson، نويسنده , , Fraser Murray، نويسنده , , Pawel Richards، نويسنده , , Alison Macaulay، نويسنده , , Keith A. Wafford، نويسنده ,
Abstract :
Novel (E)-N1-(benzyl)cinnamamidines were prepared and evaluated as NR2B subtype NMDA receptor ligands. Excellent affinity was achieved by appropriate substitution of either phenyl ring. The 2-methoxybenzyl compound 1h had 1000-fold lower IC50 in NR2B than NR2A-containing cells. Replacement of the styryl unit by 2-naphthyl was well tolerated.
