Title of article
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: A novel series of mixed dopamine D2/D4 receptor antagonist
Author/Authors
He Zhao، نويسنده , , Xiaoyan Zhang، نويسنده , , Kevin Hodgetts، نويسنده , , Andrew Thurkauf، نويسنده , , Jack Hammer، نويسنده , , Jayaraman Chandrasekhar، نويسنده , , Andrzej Kieltyka، نويسنده , , Robbin Brodbeck، نويسنده , , Stanislaw Rachwal، نويسنده , , Renee Primus، نويسنده , , Charles Manly، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
701
To page
704
Abstract
5-Piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. This series featured a rigid tricyclic ring system as an important pharmacophore core structure for high binding affinity. Molecular modeling studies are also described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792997
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