Title of article
1,4-Dibenzylpiperazines possess anticocaine activity
Author/Authors
Abby Foster، نويسنده , , Huifang Wu، نويسنده , , Weibin Chen، نويسنده , , Wanda Williams، نويسنده , , Wayne D. Bowen، نويسنده , , Rae R. Matsumoto، نويسنده , , Andrew Coop، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
749
To page
751
Abstract
N,N-Dibenzylpiperazines have high affinity for sigma receptors, and we aimed to increase their anticocaine activity by introducing substituents known to enhance such activity in other sigma ligands. Ligands with high affinity for sigma-1 receptors resulted, but their activity in attenuating cocaine-induced convulsions did not correlate with sigma-1 binding affinity, and may be more closely related to their sigma-2 binding affinities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793008
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