Title of article
Dehydrophenylalanine derivatives as VLA-4 integrin antagonists
Author/Authors
John R. Porter، نويسنده , , Sarah C. Archibald، نويسنده , , Julien A. Brown، نويسنده , , Kirstie Childs، نويسنده , , David Critchley، نويسنده , , John C. Head، نويسنده , , Ted A. H. Parton، نويسنده , , Martyn K. Robinson، نويسنده , , Anthony Shock، نويسنده , , Richard J. Taylor، نويسنده , , Graham J. Warrellow، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
805
To page
808
Abstract
We describe a series of dehydrophenylalanine derivatives where the Z isomers are potent VLA-4 antagonists but are subject to rapid biliary clearance and the E isomers have poor activity but have a slower rate of clearance. These configurationally constrained molecules have led to the design of a novel class of benzodiazepine VLA-4 antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793019
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