Author/Authors :
Bernd Büttelmann، نويسنده , , Alexander Alanine، نويسنده , , Anne Bourson، نويسنده , , Ramanjit Gill، نويسنده , , Marie-Paule Heitz، نويسنده , , Vincent Mutel، نويسنده , , Emmanuel Pinard، نويسنده , , Gerhard Trube، نويسنده , , René Wyler، نويسنده ,
Abstract :
Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the discovery of high affinity antagonists which are selective (vs α1 and M1 receptors) and active in vivo.
