Title of article
2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists
Author/Authors
Bernd Büttelmann، نويسنده , , Alexander Alanine، نويسنده , , Anne Bourson، نويسنده , , Ramanjit Gill، نويسنده , , Marie-Paule Heitz، نويسنده , , Vincent Mutel، نويسنده , , Emmanuel Pinard، نويسنده , , Gerhard Trube، نويسنده , , René Wyler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
829
To page
832
Abstract
Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the discovery of high affinity antagonists which are selective (vs α1 and M1 receptors) and active in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793025
Link To Document