Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3-Dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin

The synthesis and characterization of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin is reported. The phototoxicity on C6 cell lines and the pharmacokinetics are also reported as preliminary results showing a very high tumor to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.