Author/Authors :
Nigel Vicker، نويسنده , , Yaikat Ho، نويسنده , , James Robinson، نويسنده , , Lawrence L. W. Woo، نويسنده , , Atul Purohit، نويسنده , , Michael J. Reed، نويسنده , , Barry V. L. Potter، نويسنده ,
Abstract :
We describe the docking of selected steroidal and non-steroidal estrone sulphatase inhibitors, including the Phase I clinical trial candidate 667COUMATE (6), into the active site of human carbonic anhydrase II (hCA II). The docking scores are compared with the inhibition of hCA II and show good correlation with biological activity.
