Title of article
Bis-sulfonamides as endothelin receptor antagonists
Author/Authors
Christoph Boss، نويسنده , , Martin H. Bolli، نويسنده , , Thomas Weller، نويسنده , , Walter Fischli، نويسنده , , Martine Clozel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
951
To page
954
Abstract
Modification of the structure of bosentan 1, the first marketed endothelin receptor antagonist (Tracleer™), by introduction of a second sulfonamide function at the alkoxy side chain, led to bis-sulfonamides 2. This allowed to prepare dual ETA/ETB as well as ETB receptor selective antagonists, which could serve as tools to investigate the pharmacological consequences of selective ETB receptor blockade.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793052
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