Title of article
Synthesis and photoreactivity of caged blockers for glutamate transporters
Author/Authors
Kiyo Takaoka، نويسنده , , Yoshiro Tatsu، نويسنده , , Noboru Yumoto، نويسنده , , Terumi Nakajima، نويسنده , , Keiko Shimamoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
965
To page
970
Abstract
-TBOA ( -threo-β-benzyloxyaspartate) is, so far, the most potent non-transportable blocker for glutamate transporters. We synthesized α-CMCM- -TBOA (1a) possessing [7-(carboxymethoxy)coumarin-4-yl]methyl ester as a caging group. α-CMCM- -TBOA (1a) is biologically inactive until UV irradiation and the photolysis of 1a immediately released -TBOA to show glutamate uptake inhibition. The photoreactivity of the coumarin-type caging group was superior to that of the o-nitrobenzyl-type caging group.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793055
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