Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase

A new series of -glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney γ-glutamyltranspeptidase (GGT). Kinetic parameters (Km and kcat) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency.