Title of article
N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure–activity relationship
Author/Authors
Daniel J. Burdick، نويسنده , , Ken Paris، نويسنده , , Kenneth Weese، نويسنده , , Mark Stanley، نويسنده , , Maureen Beresini، نويسنده , , Kevin Clark، نويسنده , , Robert S. McDowell، نويسنده , , James C. Marsters Jr، نويسنده , , Thomas R. Gadek، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1015
To page
1018
Abstract
The association of ICAM-1 with LFA-1 plays a critical role in several autoimmune diseases. N-2-Bromobenzoyl -tryptophan, compound 1, was identified as an inhibitor to the formation of the LFA-1/ICAM complex. The SAR of the amino acid indicates that the carboxylic acid is required for inhibition and that -histidine is the most favored amino acid.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793064
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