Title of article
Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives
Author/Authors
Montserrat Rodriguez، نويسنده , , Daniele Bonnet-Delpon، نويسنده , , Jean-Pierre Bégué، نويسنده , , Anne Robert، نويسنده , , Bernard Meunier، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1059
To page
1062
Abstract
The alkylating properties of two artemisinin derivatives bearing a trifluoromethyl substituent at C10 were evaluated toward manganese(II) tetraphenylporphyrin, considered as a heme model. Chlorin-type covalent adducts were obtained by alkylation of the porphyrin ring by C-centered radicals derived from reductive activation of the peroxide function of the drugs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793074
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