Title of article
Synthesis and biological evaluation of 4-Deacetoxy-1,7-dideoxy azetidine paclitaxel analogues
Author/Authors
Qian Cheng، نويسنده , , Hiromasa Kiyota، نويسنده , , Marina Yamaguchi، نويسنده , , Tohru Horiguchi، نويسنده , , Takayuki Oritani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
1075
To page
1077
Abstract
Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793078
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