Title of article
Discovery of a potent and selective agonist of the prostaglandin EP4 receptor
Author/Authors
Xavier Billot، نويسنده , , Anne Chateauneuf، نويسنده , , Nathalie Chauret، نويسنده , , Danielle Denis، نويسنده , , Gillian Greig، نويسنده , , Marie-Claude Mathieu، نويسنده , , Kathleen M. Metters، نويسنده , , Deborah M. Slipetz، نويسنده , , Robert N. Young، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1129
To page
1132
Abstract
Analogues of PGE2 wherein the hydroxycyclopentanone ring has been replaced by a lactam have been prepared and evaluated as ligands for the EP4 receptor. An optimized compound (19a) shows high potency and agonist efficacy at the EP4 receptor and is highly selective over the other seven known prostaglandin receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793090
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