Title of article :
Design and Synthesis of Potent, Non-peptide Inhibitors of HCV NS3 Protease
Author/Authors :
Xiaojun Zhang، نويسنده , , Aaron C. Schmitt، نويسنده , , Wen Jiang، نويسنده , , Zelda Wasserman، نويسنده , , Carl P. Decicco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Starting from a hexapeptide boronic acid lead, 3-amino bicyclic pyrazinones as novel β-sheet dipeptide mimetics have been designed and synthesized. Side-chain manipulation of this scaffold generated a series of potent, nonpeptidic inhibitors of HCV NS3 protease.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
