Title of article
Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective IKs-blocking class III antiarrhythmic agents
Author/Authors
John W. Butcher، نويسنده , , Nigel J. Liverton، نويسنده , , David A. Claremon، نويسنده , , Roger M. Freidinger، نويسنده , , Nancy K. Jurkiewicz، نويسنده , , Joseph J. Lynch Jr.، نويسنده , , Joseph J. Salata، نويسنده , , Jixin Wang، نويسنده , , Christine M. Dieckhaus، نويسنده , , Donald E. Slaughter، نويسنده , , Kamlesh Vyas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1165
To page
1168
Abstract
Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones having various N-l substituents were identified as potent and selective blockers of the slowly activating cardiac delayed rectifier potassium current (IKs). Compound 11 is the most potent IKs channel blocker reported to date.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793098
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