Title of article :
A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin
Author/Authors :
Jutta Wanner، نويسنده , , Datong Tang، نويسنده , , Casey C. McComas، نويسنده , , Brendan M. Crowley، نويسنده , , Wanlong Jiang، نويسنده , , Jason Moss، نويسنده , , Dale L. Boger، نويسنده ,
Abstract :
A general method for the deglycosidation of glycopeptide antibiotics has been developed. Treatment of vancomycin, ristocetin, and ramoplanin with anhydrous HF results in efficient cleavage of the sugars to provide the corresponding aglycons in high yield.
