Author/Authors :
Jiandong Shi، نويسنده , , Zili Xiao، نويسنده , , Michael A. Ihnat، نويسنده , , Chandrashekhar Kamat، نويسنده , , Bulbul Pandit، نويسنده , , Zhigen Hu، نويسنده , , Pui-Kai Li، نويسنده ,
Abstract :
The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3–69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.
