Author/Authors :
Armin Reichenberg، نويسنده , , Martin Hintz، نويسنده , , Yvonne Kletschek، نويسنده , , Tanja Kuhl، نويسنده , , Christian Haug، نويسنده , , Rosel Engel، نويسنده , , Jens Moll، نويسنده , , Dmitry N. Ostrovsky، نويسنده , , Hassan Jomaa، نويسنده , , Matthias Eberl، نويسنده ,
Abstract :
The immunological characterization of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), and its methylenediphosphonate analogue, HMB-PCP, is described. With an EC50 of 0.1–0.2 nM, HMB-PP is significantly more potent in stimulating human Vγ9/Vδ2 T cells than any other compound described so far. However, replacing the pyrophosphate by a P–CH2–P function abrogates the bioactivity drastically, with HMB-PCP having a EC50 of only 5.3 μM.
