Title of article
Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human γδ T cells but does not lead to competitive antagonism
Author/Authors
Armin Reichenberg، نويسنده , , Martin Hintz، نويسنده , , Yvonne Kletschek، نويسنده , , Tanja Kuhl، نويسنده , , Christian Haug، نويسنده , , Rosel Engel، نويسنده , , Jens Moll، نويسنده , , Dmitry N. Ostrovsky، نويسنده , , Hassan Jomaa، نويسنده , , Matthias Eberl، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1257
To page
1260
Abstract
The immunological characterization of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), and its methylenediphosphonate analogue, HMB-PCP, is described. With an EC50 of 0.1–0.2 nM, HMB-PP is significantly more potent in stimulating human Vγ9/Vδ2 T cells than any other compound described so far. However, replacing the pyrophosphate by a P–CH2–P function abrogates the bioactivity drastically, with HMB-PCP having a EC50 of only 5.3 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793117
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