Author/Authors :
Andrew Fensome، نويسنده , , Marci Koko، نويسنده , , Jay Wrobel، نويسنده , , Puwen Zhang، نويسنده , , Zhiming Zhang، نويسنده , , Jeffrey Cohen، نويسنده , , Scott Lundeen، نويسنده , , Kelly Rudnick، نويسنده , , Yuan Zhu، نويسنده , , Richard Winneker، نويسنده ,
Abstract :
During the course of our studies on 3,3-disubstituted-5-aryloxindoles derived progesterone receptor (PR) antagonists we discovered that changing the amide funtionality to a thio-amide resulted in compounds displaying potent PR agonist activity. In this communication, the synthesis, structure activity relationships (SAR) and in vivo activity of various 5-arylthio-oxindoles will be discussed.
