• Title of article

    Design, synthesis and biological activity of β-carboline-based type-5 phosphodiesterase inhibitors

  • Author/Authors

    Graham N. Maw، نويسنده , , Charlotte M. N. Allerton، نويسنده , , Eugene Gbekor، نويسنده , , William A. Million، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2003
  • Pages
    4
  • From page
    1425
  • To page
    1428
  • Abstract
    The SAR of a series of β-carboline derived type 5 phosphodiesterase inhibitors has been explored and we have discovered compounds with excellent levels of PDE5 potency and selectivity over PDE6. However, the series exhibits low levels of selectivity over PDE11, a phosphodiesterase with unknown function.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2003
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    793155

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=793155