First enantiodivergent Baeyer–Villiger oxidation by recombinant whole-Cells expressing two monooxygenases from Brevibacterium

Microbial Baeyer–Villiger oxidations of representative mesomeric ketones with recombinant Escherichia coli cells expressing two monooxygenases from Brevibacterium were investigated. The two enzymes displayed enantiodivergent biotransformations on an array of structurally diverse substrates, allowing access to some key lactone intermediates in natural compound synthesis.