Title of article :
A novel metal-Chelating inhibitor of protein farnesyltransferase
Author/Authors :
Akiyuki Hamasaki، نويسنده , , Hayato Naka، نويسنده , , Fuyuhiko Tamanoi، نويسنده , , Kazuo Umezawa، نويسنده , , Masami Otsuka، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
A novel metal chelator comprising a 4-(naphthalen-1-yl)pyridine and 2-aminoethanethiol was synthesized. This showed inhibitory activity against human protein farnesyltransferase with IC50 1.9 μM, induced morphological change in K-ras-NRK cells at 0.5 μg/mL and showed growth inhibition of K-ras-NRK cells with IC50 0.32 μg/mL.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
