Author/Authors :
JungWha Yoon، نويسنده , , HyeYoung Choi، نويسنده , , Hyun Joo Lee، نويسنده , , Chong Hyun Ryu، نويسنده , , Hyeung-geun Park، نويسنده , , Young-Ger Suh، نويسنده , , Uhtaek Oh، نويسنده , , Yeon Su Jeong، نويسنده , , Jin Kyu Choi، نويسنده , , Young-Ho Park، نويسنده , , Hee-Doo Kim، نويسنده ,
Abstract :
A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showed a 6.3 μM of IC50 value in 45Ca2+-influx assay.
