Title of article
Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme mur D
Author/Authors
James R. Horton، نويسنده , , Julieanne M. Bostock، نويسنده , , Ian Chopra، نويسنده , , Lars Hesse، نويسنده , , Simon E. V. Phillips، نويسنده , , David J. Adams and ...[et al.]، نويسنده , , A. Peter Johnson، نويسنده , , Colin W. G. Fishwick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
1557
To page
1560
Abstract
Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793184
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