Author/Authors :
Nigel E. Austin، نويسنده , , Michael S. Hadley، نويسنده , , John D. Harling، نويسنده , , Frank P. Harrington، نويسنده , , Gregor J. Macdonald، نويسنده , , Darren J. Mitchell، نويسنده , , Graham J. Riley، نويسنده , , Tania O. Stean، نويسنده , , Geoffrey Stemp، نويسنده , , Sharon C. Stratton، نويسنده , , Mervyn Thompson، نويسنده , , Neil Upton، نويسنده ,
Abstract :
Starting from a series of 7-linked tetrahydroisoquinoline derivatives, as exemplified by SB-270664, a new series of 8,8-dimethylnaphthyridine compounds has been identified. SAR studies around these attractive leads have provided compounds such as 12 which display excellent anticonvulsant activity and an encouraging pharmacokinetic profile in vivo.
