Author/Authors :
Nakjeong Kim، نويسنده , , Sunkyung Lee، نويسنده , , Kyu Yang Yi، نويسنده , , Sung-eun Yoo، نويسنده , , Guncheol Kim، نويسنده , , Chong-Ock Lee، نويسنده , , Sung Hee Park، نويسنده , , Byung-Ho Lee، نويسنده ,
Abstract :
A series of 4-(N-imidazol-2-ylmethyl)aminobenzopyran analogues, originally designed as KATP openers for ischemic diseases, showed antiangiogenic properties through the inhibition of HUVEC tube formation. Especially one of p-Cl substituted analogues (4c) completely inhibited HUVEC tube formation at 10 μM. The compound 4c significantly inhibited tumor growth by 52% on A549 (human non small cell lung carcinoma) in nude mice xenografts without any significant side effects.
