Title of article :
Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
Author/Authors :
Vedula M. Sharma، نويسنده , , K. V. Adi Seshu، نويسنده , , C. Vamsee Krishna، نويسنده , , P. Prasanna، نويسنده , , V. Chandra Sekhar، نويسنده , , A. Venkateswarlu، نويسنده , , Sriram Rajagopal، نويسنده , , R. Ajaykumar، نويسنده , , Dhanvanthri S. Deevi، نويسنده , , N. V. S. Rao Mamidi، نويسنده , , R. Rajagopalan، نويسنده ,
Abstract :
A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Compounds 18, 21, 28, 29, 30 and 31 showed cytotoxic activity with GI50 values in the range of 2.1–8.1 μM concentration. Among these, compounds 21 and 28 exhibited good pharmacokinetic properties. These compounds were further evaluated for their in vivo efficacy in modified hollow fibre assay (HFA).
