Author/Authors :
Robert J. Kerns، نويسنده , , Michael J. Rybak، نويسنده , , Glenn W. Kaatz، نويسنده , , Flamur Vaka، نويسنده , , Raymond Cha، نويسنده , , Richard G. Grucz، نويسنده , , Veena U. Diwadkar، نويسنده , , Tracey D. Ward، نويسنده ,
Abstract :
The synthesis of symmetric and asymmetric piperazinyl-linked dimers of the fluoroquinolone class of antibiotics is described. Specific dimers are shown to possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus, including strains possessing resistance due to the NorA multidrug efflux pump and a mutation in the quinolone resistance-determining region of topoisomerase IV.
