-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety
Author/Authors :
Udo E. W. Lange، نويسنده , , Dorit Baucke، نويسنده , , Wilfried Hornberger، نويسنده , , Helmut Mack، نويسنده , , Werner Seitz، نويسنده , , H. Wolfgang H?ffken، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
5
From page :
2029
To page :
2033
Abstract :
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin–inhibitor complex X-ray structures.
