Title of article :
3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site
Author/Authors :
Stephen W. Wright، نويسنده , , Anthony A. Carlo، نويسنده , , Dennis E. Danley، نويسنده , , David L. Hageman، نويسنده , , George A. Karam، نويسنده , , Mahmoud N. Mansour، نويسنده , , Lester D. McClure، نويسنده , , Jayvardhan Pandit، نويسنده , , Gayle K. Schulte، نويسنده , , Judith L. Treadway، نويسنده , , Ing-Kae Wang، نويسنده , , Paul H. Bauer، نويسنده ,
Abstract :
3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.
