Title of article :
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore
Author/Authors :
Lin Zhi، نويسنده , , Josef D. Ringgenberg، نويسنده , , James P. Edwards، نويسنده , , Christopher M. Tegley، نويسنده , , Sarah J. West، نويسنده , , Barbara Pio، نويسنده , , Mehrnouch Motamedi، نويسنده , , Todd K. Jones، نويسنده , , Keith B. Marschke، نويسنده , , Dale E. Mais، نويسنده , , William T. Schrader، نويسنده ,
Abstract :
A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified by modification of the substituents at the D-ring.
