Title of article
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
Author/Authors
Dina Manetti، نويسنده , , Elisabetta Martini، نويسنده , , Carla Ghelardini، نويسنده , , Silvia Dei، نويسنده , , Nicoletta Galeotti، نويسنده , , Luca Guandalini، نويسنده , , Maria Novella Romanelli، نويسنده , , Serena Scapecchi، نويسنده , , Elisabetta Teodori، نويسنده , , Alessandro Bartolini، نويسنده , , Fulvio Gualtieri، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2303
To page
2306
Abstract
Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimerʹs disease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793344
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