Author/Authors :
Bryan K. Sorensen، نويسنده , , J. T. Link، نويسنده , , Thomas von Geldern، نويسنده , , Maurice Emery، نويسنده , , Jiahong Wang، نويسنده , , Bach Hickman، نويسنده , , Marlena Grynfarb، نويسنده , , Annika Goos-Nilsson، نويسنده , , Sherry Carroll، نويسنده ,
Abstract :
A β-C-glucuronide conjugate of the glucocorticoid receptor antagonist, Mifepristone 1, was prepared which maintained binding affinity, had modest in vitro activity, and was metabolically more stable than the parent. Pharmacokinetic studies suggest that the conjugate is recognized by the liver like O-glucuronides and may undergo a portion of the enterohepatic recirculation loop.
