Title of article
Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors
Author/Authors
Tatsuzo Ukita، نويسنده , , Masakatsu Sugahara، نويسنده , , Yoshihiro Terakawa، نويسنده , , Tooru Kuroda، نويسنده , , Kazuteru Wada، نويسنده , , Aya Nakata، نويسنده , , Hideo Kikkawa، نويسنده , , Katsuo Ikezawa، نويسنده , , Kazuaki Naito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2347
To page
2350
Abstract
A novel series of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives has been prepared. These compounds showed potent PDE4 inhibitory activities and a broad margin between the Ki value of the rolipram binding affinity and the IC50 value of PDE4 inhibition. They also exhibited potent inhibitory activities toward LPS-induced TNF-α production in mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793353
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