Author/Authors :
G. Durand، نويسنده , , A. Polidori، نويسنده , , J. P. Salles، نويسنده , , M. Prost، نويسنده , , H. G. Diem and P. Durand ، نويسنده , , B. Pucci، نويسنده ,
Abstract :
The synthesis of a new amphiphilic antioxidant called PBNLP and derived from both α-phenyl-N-tert-butyl nitrone (PBN) and lipoic acid was described. Grafting a lactobionamide moiety onto the aromatic group of the PBN provided the water solubility of this compound. In vitro preliminary biological evaluations of its antioxidant capacity were performed using the KRL biological test based on free radical-induced hemolysis. The PBNLP induces a protection of erythrocytes against exogenous free radicals higher than that measured with lipoic acid or PBN alone or with lipoic acid or PBN derivatives in admixtures.
