Author/Authors :
David R. Mole، نويسنده , , Imre Schlemminger، نويسنده , , Luke A. McNeill، نويسنده , , Kirsty S. Hewitson، نويسنده , , Christopher W. Pugh، نويسنده , , Peter J. Ratcliffe، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده ,
Abstract :
Hydroxylation of hypoxia-inducible factor, a nuclear transcription factor, is catalysed by iron and 2-oxoglutarate dependent hydroxylases. Various analogues of the 2-oxoglutarate cosubstrate were synthesised and shown to inhibit the activity of human hypoxia-inducible factor-1α prolyl hydroxylases in cell-free extracts.
