Author/Authors :
Gunther Bal، نويسنده , , Pieter Van der Veken، نويسنده , , Dimitri Antonov، نويسنده , , Anne-Marie Lambeir، نويسنده , , Philippe Grellier، نويسنده , , Simon L. Croft، نويسنده , , Koen Augustyns، نويسنده , , Achiel Haemers، نويسنده ,
Abstract :
Prolylprolylisoxazoles and prolylprolylisoxazolines were synthesized through a 1,3-dipolar cycloaddition reaction. These compounds are potent inhibitors of human and trypanosomal prolyloligopeptidase. They were shown to inhibit Trypanosoma cruzi and Trypanosoma b. brucei in in vitro systems with ED50ʹs in the lower μM range.
