Author/Authors :
Rahime Simsek، نويسنده , , Jean Chang-Fong، نويسنده , , Mase Lee، نويسنده , , Malgorzata Dukat، نويسنده , , M. Imad Damaj، نويسنده , , Billy R. Martin، نويسنده , , Richard A. Glennon، نويسنده ,
Abstract :
Quaternization via N-methylation of the terminal amines of a series of 3-(dialkylaminoethoxy)pyridines resulted in analogues that displayed up to 50–60-fold enhanced affinity for nicotinic acetylcholinergic (nACh) receptors. Several of these compounds displayed antinociceptive properties in mice using the tail-flick assay and serve as possible leads for the development of novel analgesic agents.
