Title of article :
Synthesis of three enantiomeric pairs of scyllo-Inositol phosphate and molecular interactions between all possible regioisomers of scyllo-Inositol phosphate and inositol 1,4,5-Trisphosphate 3-Kinase
Author/Authors :
Yong-Uk Kwon، نويسنده , , Jungkyun Im، نويسنده , , Gildon Choi، نويسنده , , Young-Soo Kim، نويسنده , , Kwan Yong Choi، نويسنده , , Sung-Kee Chung، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regioisomers including three enantiomeric pairs: scyllo-I(1,2)P2, scyllo-I(1,2,4)P3, scyllo-I(1,2,3,4)P4. We herein describe the facile synthetic routes to the three enantiomeric pairs of scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters