Title of article
Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and x-ray crystallographic analysis
Author/Authors
Jun Tang، نويسنده , , Lisa M. Shewchuk، نويسنده , , Hitoshi Sugawara and Hideyuki Sato، نويسنده , , Masaichi Hasegawa، نويسنده , , Yoshiaki Washio، نويسنده , , Naohiko Nishigaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
2985
To page
2988
Abstract
A novel series of anilinopyrazoles has been designed based on the X-ray crystal structure analysis. Most compounds from this series not only show sub-nanomolar IC50 values for CDK2, but also demonstrate almost 1000-fold selectivity to other kinases including CDK1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
793492
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